Early Intervention for Psychosis with N-Methyl-D-Aspartate Receptor Modulators
نویسندگان
چکیده
منابع مشابه
Early Intervention for Psychosis with N-Methyl-D-Aspartate Receptor Modulators
TO THE EDITOR Accumulating evidence suggests that patients with schizophrenia exhibit nonpsychotic, nonspecific prodromal symptoms for several years before the onset of frank psychosis. A meta-analysis demonstrated that cognitive impairment is a common feature of the prodromal state of psychosis. Accordingly, interest in the potential benefit of early intervention in psychosis is increasing. We...
متن کاملCombined Therapy for Anti-N-methyl D-aspartate Receptor Encephalitis
Background Anti-N-methyl- d-aspartate receptor (anti-NMDAR) encephalitis is an autoimmune neurological disorder that usually occurs as a paraneoplastic syndrome and is particularly associated with ovarian teratoma. Standard therapy for severe cases is not established and the prognosis in patients who do not respond to first-line treatment is poor. Case Report An 11-year-old boy complained ps...
متن کاملMechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators.
The compound 4-(5-(4-bromophenyl)-3-(6-methyl-2-oxo-4-phenyl-1,2-dihydroquinolin-3-yl)-4,5-dihydro-1H-pyrazol-1-yl)-4-oxobutanoic acid (DQP-1105) is a representative member of a new class of N-methyl-d-aspartate (NMDA) receptor antagonists. DQP-1105 inhibited GluN2C- and GluN2D-containing receptors with IC(50) values that were at least 50-fold lower than those for recombinant GluN2A-, GluN2B-, ...
متن کاملAnti-N-Methyl-D-Aspartate-Receptor Encephalitis, a Challenge for Neurologists or a Chameleon for Psychiatrists: A Case Report
Anti-N-Methyl-D-Aspartate-Receptor (NMDA-R) encephalitis is a new autoimmune disorder, often paraneoplastic in nature, presenting with complex neuropsychiatric symptoms. Diagnosed serologically, this disorder is often responsive to immunosuppressant treatment. We here in report the case of a 56-year-old man with anti NMDA-R encephalitis presenting initially with disorientation and hallucinati...
متن کاملAmelioration of Pentylenetetrazole-Induced Seizures by Modulators of Sigma, N-Methyl-D-Aspartate, and Ryanodine Receptors in Mice
Background: Sigma receptors, N-methyl-D-aspartate (NMDA) antagonist, and modulators of intracellular calcium may be useful for seizure control. Therefore, we aimed to evaluate the antiepileptic effects of opipramol, a sigma receptor agonist, against pentylenetetrazole (PTZ)-induced seizures in mice and assess ketamine and caffeine interaction with the antiepileptic effects of opipramol.Methods:...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Psychopharmacology and Neuroscience
سال: 2015
ISSN: 1738-1088,2093-4327
DOI: 10.9758/cpn.2015.13.3.328